脑部放疗，上午比下午敏感许多！* n1 |# S& w% `3 |( G+ d
; }% |1 u4 X0 m& j
, J" n8 E# A& F& HCancer 2011 Jan 15;117(2):414-20. doi: 10.1002/cncr.25423. Epub 2010 Sep 9.5 L! q! h$ U' n0 U* s, t
Gamma knife radiosurgery for brain metastasis of nonsmall cell lung cancer: is there a difference in outcome between morning and afternoon treatment?8 K; o2 `" j- |5 ^; |6 C) ]5 H
Rahn DA 3rd, Ray DK, Schlesinger DJ, Steiner L, Sheehan JP, O'Quigley JM, Rich T.; Z: V% F, X0 {* h' u) a- g7 t
SourceDepartment of Radiation Oncology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA.
3 O* |6 w0 G/ V$ m, @
" R- f& @ r. G, U( QAbstract p& e v: x3 n; i
BACKGROUND: Circadian cell-cycle progression causes fluctuating radiosensitivity in many tissues, which could affect clinical outcomes. The purpose of this study was to determine whether outcomes of single-session gamma knife radiosurgery (GKRS) for metastatic nonsmall cell lung cancer (NSCLC) differ based on treatment time.& o+ N2 l ]* s( H! s j$ V- _
% t! M3 s- U% C( s' S3 r; ^7 ZMETHODS: Fifty-eight patients received GKRS between 10:00 am and 12:30 pm and 39 patients received GKRS between 12:30 pm and 3:00 pm. The mean peripheral dose was 18.6 Gy. The mean tumor size was 7.3 cm³. Magnetic resonance imaging was used to score local control at 3 months. Cause of death (COD) was categorized as central nervous system (CNS)-related or systemic.8 J9 a7 ^! V0 D9 c5 T+ s# S
! B- Z0 h2 q5 ~& R# [3 ]) Y+ {RESULTS: Demographic and disease characteristics of the 2 groups were similar. Local control at 3 months was achieved in 97% (35/36) of patients who underwent GKRS early in the day versus 67% (8/12) of patients who underwent GKRS later in the day (chi-square, P = .014). Early GKRS was associated with better survival (median 9.5 months) than late GKRS (median 5 months) (Kaplan-Meier log-rank test, P = .025). Factors contributing to better survival in a Cox regression model included early treatment time (P = .004) and recursive partition analysis class (P < .001). Cause of death in the early treatment group was CNS-related in 6% (3/47) of patients versus 24% (8/34) of patients in the late treatment group (chi-square test, P = .026).9 J& s9 R: [% Y, p' \
7 A9 _. ^8 U& G! N/ T! \3 d4 FCONCLUSIONS: GKRS for metastatic NSCLC had better local control, better survival, and a lower rate of CNS-related cause of death when given earlier in the day versus later in the day. These retrospective data should encourage future study in brain radiosurgery and non-CNS stereotactic body radiotherapy series.
; _2 s' `/ x5 K2 k! _% v* R' _) _% J0 h6 v' L$ {4 p; G/ f
|
抗炎食谱--#姜黄牛里脊杂蔬汤
营养食谱--#姜黄牛里脊杂蔬汤
所需食材：
牛里脊肉75g，西蓝花50g，去籽彩椒50g
肺癌5、8、10年的路线展望---奥西伏
前几天和我一姐姐吃饭聊天，唉，吃着吃着又聊到我俩的共同伤心事了，她妈去年也得
脑膜转移诊疗潘振宇教授科普总结
脑膜转移诊疗潘振宇教授科普总结
脑膜转移 中位治疗生存期 3-6月
脑膜转移的临床表现
干货分享！骆涛波教授带你掌握肺癌防
作者：雨过天晴体检发现肺结节，什么情况下需要切除？家人患有肺癌，自己是否也属于高
新靶点，新药物，能否为各类肺癌患者
作者：seacat
MTAP缺失（MTAP del）广泛存在于多种实体瘤中，而在非小细胞肺癌中检出
3 s* N7 m7 `6 s0 p6 ?
显身卡
