发给老马备查:( l, q- A( G4 o0 K
滴水察海(69304838) 15:23:23
, Q& X! B0 ?4 |; ?, [老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱# U- p6 M% W1 e2 q3 {
吉非替尼和S-1连用的依据
4 \: p) G* S8 Z" `! i( ]) l! gGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
( q& a4 M y( u3 m9 W: O/ _是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达2 V& l9 ^+ M& f' D: j. q' ^2 {4 k2 q' k
这样是不是推理出,耐药后,可以用S-1和培美了?
3 J! c6 b# z1 P0 W( H: S( L7 Z. r结论:4 ?0 o$ J, j: P( @* w
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |